Two new articles have been published in Journal of Medicinal Chemistry (links below). The articles are based on the findings our team members received at AstraZeneca just before joining Sprint Bioscience.
New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain
http://pubs.acs.org/doi/abs/10.1021/jm300991n
Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides
